The need for standardisation in life science research – an approach to excellence and trust

Today, tutorial researchers profit from the modifications pushed by digital applied sciences and the large progress of information and knowledge, on globalisation, enlargement of the scientific neighborhood, and the linkage between totally different scientific communities and the society. To totally profit from this improvement, nevertheless, data wants to be shared overtly and transparently. Digitalisation performs a significant position right here as a result of it permeates all areas of enterprise, science and society and is among the key drivers for innovation and worldwide cooperation.

To handle the ensuing alternatives, the EU promotes the event and use of collaborative methods to produce and share information and knowledge as early as attainable in the research course of, but additionally to appropriately safe outcomes with the European technique for Open Science (OS). It is now broadly recognised that making research outcomes extra accessible to all societal actors contributes to simpler and environment friendly science; it additionally serves as a lift for innovation in the general public and personal sectors. However for research knowledge to be findable, accessible, interoperable and reusable using requirements is crucial. At the metadata stage, appreciable efforts in standardisation have already been made (e.g. Data Management Plan and FAIR Principle and so forth.)

whereas in context with the uncooked knowledge these elementary efforts are nonetheless fragmented and in some circumstances utterly lacking. The CHARME consortium, funded by the European Cooperation in Science and Technology (COST) Agency, has recognized wants and gaps in the sphere of standardisation in the life sciences and additionally mentioned potential hurdles for implementation of requirements in present observe. Here, the authors recommend 4 measures in response to present challenges to guarantee a top quality of life science research knowledge and their re-usability for research and innovation.

Category principle and foundations of life science: A structuralist perspective on cognition

Category principle has lately been utilized efficiently past arithmetic and its foundations, for instance, in quantum physics, quantum computing, linguistics, and pure language processing in synthetic intelligence. Category principle right this moment is arguably foundations of science in addition to foundations of arithmetic. Yet functions of class principle to the life sciences are nonetheless restricted, and there are seemingly no clearly profitable paradigmatic circumstances of them. Here we handle foundational elements of class principle in and throughout the sciences, and potential structural interconnections between class principle and the life sciences, in explicit cognitive science.

More particularly, we first handle the 2 elements of class principle as foundations of science and as foundations of arithmetic in explicit, and then talk about what class principle may do for foundations of life science, in explicit cognitive science. We suggest, amongst different issues, a categorical structuralist approach to the thoughts-physique drawback as an various to reductionist approaches, which is arguably of each scientific and metaphysical significance on the identical time.

Category principle permits us to elucidate structural interconnections between the legal guidelines of cognition and the legal guidelines of actuality, thus paving the way in which for overcoming the Cartesian dualism separating the cognitive and bodily worlds. Put one other approach, class principle means that there could also be larger legal guidelines governing each worlds directly; the upper structuralist principle of cognition might embody the double side principle of data by David Chalmers.

 The need for standardisation in life science research - an approach to excellence and trust

Journal publication ethics and implications for life science researchers: a COPE perspective

The high quality of the research report in the type of peer-reviewed journal archives is a mirrored image of not solely the standard of the research publication and correction course of, but additionally the standard of the underlying information creation course of. Key to the integrity of the research report are honesty and accountability from all events concerned in governing, performing, and publishing scholarly work. A concerted effort is required to nurture an moral research publishing tradition by selling moral observe, related coaching, and efficient methods for responding to allegations of research or publication misconduct.

The Committee on Publication Ethics (COPE) is a membership organisation that goals to promote integrity in research publishing, for instance, by growing and encouraging greatest practices to be certain that research is reported ethically, utterly, and transparently. COPE makes use of the Principles of Transparency and Best Practice in Scholarly Publishing as a part of its standards when evaluating publishers and journals as members. Researchers may make use of those tips to assess a journal’s high quality and to acquire insights into what peer-reviewed journals anticipate from authors.

ELISA kit for HIS (Histamine)
E-EL-0032 1 plate of 96 wells
EUR 377
  • Gentaur's HIS ELISA kit utilizes the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with HIS. During the reaction, HIS in the sample or standard competes with a fixed amount of HIS on the solid phase suppo
  • Show more
Description: A competitive ELISA kit for quantitative measurement of HIS (Histamine) in samples from Serum, Plasma, Cell supernatant
ELISA kit for General Histamine
EK2448 96 tests
EUR 603
Description: Enzyme-linked immunosorbent assay kit for quantification of General Histamine in samples from serum, plasma, tissue homogenates and other biological fluids.
ELISA kit for Human Histamine
KTE62938-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Histamine
KTE62938-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Histamine
KTE62938-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Histamine
KTE101102-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Histamine
KTE101102-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Histamine
KTE101102-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Histamine
KTE71604-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Histamine
KTE71604-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Histamine
KTE71604-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Histamine
20-abx182483
  • EUR 829.00
  • EUR 258.00
  • EUR 551.00
  • 10 g
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.
Histamine
HY-B1204 10mM/1mL
EUR 126
Histamine
RA22939 100 ul
EUR 409
Histamine
HB0500 1g
EUR 126.56
  • Product category: Biochemicals/Amino Acids/Derivatives
ELISA kit for General HA (Histamine)
ELK7869 1 plate of 96 wells
EUR 372
  • A monoclonal antibody specific to Histamine (HA) has been pre-coated onto a microplate. A competitive inhibition reaction is launched between biotin labeled Histamine (HA) and unlabeled Histamine (HA) (Standards or samples) with the pre-coated antibo
  • Show more
Description: A competitive Inhibition ELISA kit for detection of Histamine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for General HA (Histamine)
ELK8094 1 plate of 96 wells
EUR 372
  • A monoclonal antibody specific to Hyaluronic Acid (HA) has been pre-coated onto a microplate. A competitive inhibition reaction is launched between biotin labeled Hyaluronic Acid (HA) and unlabeled Hyaluronic Acid (HA) (Standards or samples) with the
  • Show more
Description: A competitive Inhibition ELISA kit for detection of Histamine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Histamine antibody
20R-HR017 50 uL
EUR 918
Description: Rabbit polyclonal Histamine antibody
Histamine 2HCl
B1561-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Histamine 2HCl
B1561-50 50 mg
EUR 128
Description: Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Histamine 2HCl
B1561-S Evaluation Sample
EUR 81
Description: Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Histamine Phosphate
B1770-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
Histamine Phosphate
B1770-50 50 mg
EUR 128
Description: Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
Histamine-BSA
80-1460 1 mg
EUR 349
Description: BSA conjugated Histamine Hapten
Histamine-OVA
80-1461 1 mg
EUR 349
Description: OVA conjugated Histamine Hapten
Histamine-OVA
80-1462 1 mg
EUR 349
Description: OVA conjugated Histamine Hapten
Histamine (BSA)
20-abx165751
  • EUR 551.00
  • EUR 244.00
  • EUR 1595.00
  • EUR 648.00
  • EUR 411.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Histamine (OVA)
20-abx165752
  • EUR 551.00
  • EUR 244.00
  • EUR 1595.00
  • EUR 648.00
  • EUR 411.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Histamine (phosphate)
HY-A0129 1g
EUR 119
Histamine antibody
PAab09932 100 ug
EUR 386
Histamine diphosphate
HB0502 5g
EUR 63.92
  • Product category: Biochemicals/Misc. Biochemicals
Vatalanib Dihydrochloride
2025-25
EUR 305
Vatalanib Dihydrochloride
2025-5
EUR 126
1400W dihydrochloride
2055-25
EUR 338
1400W dihydrochloride
2055-5
EUR 126
Norquetiapine dihydrochloride
2362-250
EUR 414
Norquetiapine dihydrochloride
2362-50
EUR 142
Berbamine dihydrochloride
2520-100
EUR 131
Berbamine dihydrochloride
2520-500
EUR 370
Antipain dihydrochloride
2834-25
EUR 327
Antipain dihydrochloride
2834-5
EUR 120
Dorsmorphin dihydrochloride
2835-25
EUR 588
Dorsmorphin dihydrochloride
2835-5
EUR 185
GGACK Dihydrochloride
1847-5 5 mg
EUR 319
  • Frequently asked questions for this product: Is the GGACK Dihydrochloride cell-permeable? - No
  • Is this item a salt form of GGACK Dihydrochloride? - Yes
  • Does this product have/require an MSDS? - Yes
  • What is the biological function of this molecul
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Description: A potent and irreversible inhibitor of Urokinase (uPA (IC??<1 µM), Factor VIIa, Factor IXa, Factor Xa, and trypsin.
PPACK Dihydrochloride
1848-5
EUR 251
Puromycin Dihydrochloride
1860-100
EUR 272
Puromycin Dihydrochloride
1860-1000
EUR 1295
Puromycin Dihydrochloride
1860-25
EUR 126
Puromycin Dihydrochloride
1860-250
EUR 457
Puromycin Dihydrochloride
1860-500
EUR 805
Emetine dihydrochloride
1970-250
EUR 359
Emetine dihydrochloride
1970-50
EUR 137
Dexpramipexole dihydrochloride
B2215-25
EUR 457
Dexpramipexole dihydrochloride
B2215-5
EUR 153
Daclatasvir dihydrochloride
B2224-25
EUR 414
Daclatasvir dihydrochloride
B2224-5
EUR 142
Netarsudil dihydrochloride
B2387-25
EUR 457
Netarsudil dihydrochloride
B2387-5
EUR 153
Furamidine dihydrochloride
B2581-25
EUR 544
Furamidine dihydrochloride
B2581-5
EUR 175
Vanoxerine dihydrochloride
B3248-10 10 mg
EUR 118
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Vanoxerine dihydrochloride
B3248-25 25 mg
EUR 210
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Vanoxerine dihydrochloride
B3248-50 50 mg
EUR 332
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Spectinomycin dihydrochloride
B3342-1000 1 g
EUR 150
Description: Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Spectinomycin dihydrochloride
B3342-5.1 10 mM (in 1mL H2O)
EUR 168
Description: Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Spectinomycin dihydrochloride
B3342-5000 5 g
EUR 283
Description: Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Pentamidine dihydrochloride
B3416-50 50 mg
EUR 128
Description: Pentamidine Dihydrochloride(MP601205 dihydrochloride) is an antimicrobial agent.
Mizolastine dihydrochloride
B1116-100 100 mg
EUR 238
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Mizolastine dihydrochloride
B1116-200 200 mg
EUR 390
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Mizolastine dihydrochloride
B1116-500 500 mg
EUR 653
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
IT1t dihydrochloride
B5650-10 10 mg
EUR 321
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
IT1t dihydrochloride
B5650-100 100 mg
EUR 1750
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
IT1t dihydrochloride
B5650-25 25 mg
EUR 592
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
IT1t dihydrochloride
B5650-5 5 mg
EUR 203
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
IT1t dihydrochloride
B5650-5.1 10 mM (in 1mL DMSO)
EUR 218
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
IT1t dihydrochloride
B5650-50 50 mg
EUR 1027
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Cystamine dihydrochloride
B5785-5.1 10 mM (in 1mL DMSO)
EUR 108
Cystamine dihydrochloride
B5785-50 50 mg
EUR 112
Fluphenazine dihydrochloride
B6132-100 100 mg
EUR 150
Description: EC50: 1.24 ?MFluphenazine is a dopamine D1 and D2 receptor inhibitor.Dopamine D1 and D2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons.
Fluphenazine dihydrochloride
B6132-5.1 10 mM (in 1mL DMSO)
EUR 168
Description: EC50: 1.24 ?MFluphenazine is a dopamine D1 and D2 receptor inhibitor.Dopamine D1 and D2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons.
Dilazep dihydrochloride
B6316-50 50 mg
EUR 268
Dimaprit dihydrochloride
B6328-100 100 mg
EUR 268
Naloxonazine dihydrochloride
B6366-10 10 mg
EUR 221
Naloxonazine dihydrochloride
B6366-50 50 mg
EUR 772
Ethambutol dihydrochloride
E005-100G 100 g
EUR 424
Ethambutol dihydrochloride
E005-25G 25 g
EUR 143
Piperazine Dihydrochloride
abx180858-100g 100 g
EUR 230
  • Shipped within 1-2 weeks.
Pramipexole dihydrochloride
20-abx180860
  • EUR 453.00
  • EUR 230.00
  • EUR 370.00
  • 10 g
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.
Vatalanib Dihydrochloride
20-abx076544
  • EUR 258.00
  • EUR 495.00
  • 10 mg
  • 50 mg
  • Shipped within 5-12 working days.
DMPQ Dihydrochloride
20-abx076714
  • EUR 578.00
  • EUR 272.00
  • 25 mg
  • 5 mg
  • Shipped within 5-12 working days.
H89 Dihydrochloride
20-abx076747
  • EUR 676.00
  • EUR 300.00
  • 25 mg
  • 5 mg
  • Shipped within 5-12 working days.
Naftopidil Dihydrochloride
E1KS1387 25mg
EUR 247
Cefotiam Dihydrochloride
C095-100MG 100 mg
EUR 232
Cefotiam Dihydrochloride
C095-50MG 50 mg
EUR 144
Chlorhexidine Dihydrochloride
C157-25G 25 g
EUR 185
Chlorhexidine Dihydrochloride
C157-5G 5 g
EUR 72
Piribedil dihydrochloride
B6557-10 10 mg
EUR 139
Piribedil dihydrochloride
B6557-100 100 mg
EUR 215
Piribedil dihydrochloride
B6557-200 200 mg
EUR 337
Piribedil dihydrochloride
B6557-5.1 10 mM (in 1mL DMSO)
EUR 150
Piribedil dihydrochloride
B6557-50 50 mg
EUR 186
Piribedil dihydrochloride
B6557-500 500 mg
EUR 563
Pirenzepine dihydrochloride
B6582-100 100 mg
EUR 134
Pirenzepine dihydrochloride
B6582-5.1 10 mM (in 1mL DMSO)
EUR 150
Pirenzepine dihydrochloride
B6582-500 500 mg
EUR 183
Telenzepine dihydrochloride
B6606-10 10 mg
EUR 161
Telenzepine dihydrochloride
B6606-50 50 mg
EUR 480
DMPQ dihydrochloride
B6642-10 10 mg
EUR 186
DMPQ dihydrochloride
B6642-5 5 mg
EUR 154
GNTI dihydrochloride
B6669-10 10 mg
EUR 383
GNTI dihydrochloride
B6669-50 50 mg
EUR 1455
1400W dihydrochloride
B6730-10 10 mg
EUR 142
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
1400W dihydrochloride
B6730-100 100 mg
EUR 728
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
1400W dihydrochloride
B6730-50 50 mg
EUR 438
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
Rimcazole dihydrochloride
B6765-10 10 mg
EUR 324
Rimcazole dihydrochloride
B6765-50 50 mg
EUR 1211
Zimelidine dihydrochloride
B6851-10 10 mg
EUR 177
Zimelidine dihydrochloride
B6851-50 50 mg
EUR 593
MPP dihydrochloride
B6910-10 10 mg
EUR 318
MPP dihydrochloride
B6910-50 50 mg
EUR 1178
Linopirdine dihydrochloride
B6916-10 10 mg
EUR 273
Linopirdine dihydrochloride
B6916-5 5 mg
EUR 187
Zoniporide dihydrochloride
B7160-10 10 mg
EUR 389
Zoniporide dihydrochloride
B7160-50 50 mg
EUR 1476
Flupenthixol dihydrochloride
B7578-50 50 mg
EUR 129
Description: MIC: 10-100 ?g/mL in most of the strainsFlupenthixol, introduced in 1965 by Lundbeck, marketed under brand names such asDepixol.Flupenthixolis atypical antipsychoticdrugof thethioxantheneclass.
Puromycin dihydrochloride
B7587-5.1 10 mM (in 1mL H2O)
EUR 119
Description: Puromycin dihydrochloride [1] is an analog of aminoacyl-tRNA.
Puromycin dihydrochloride
B7587-50 50 mg
EUR 131
Description: Puromycin dihydrochloride [1] is an analog of aminoacyl-tRNA.
Veliparib dihydrochloride
A3958-10 10 mg
EUR 148
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Veliparib dihydrochloride
A3958-200 200 mg
EUR 835
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Veliparib dihydrochloride
A3958-5 5 mg
EUR 125
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.

The current article outlines and discusses these tips to assist life science researchers publish ethically, in addition to to determine moral journals as readers, authors, and reviewers. We define latest developments in scholarly publishing that we expect will enhance the working surroundings and profession prospects for life scientists. Most prominently, we talk about two key developments. (1) Life scientists at the moment are embracing a preprint tradition main to fast dissemination of research findings. (2) We define steps to overcome the reproducibility disaster. We additionally briefly describe different improvements in scholarly publishing, together with modifications to open entry mandates from funding companies.